NMNH makes a noticeable and visible difference to the way I not only feel, but I swear it turns back the clock on my skin, also. I take it first thing in the AM on an empty stomach, followed by R-ALA and NAC, then take trans-resveratrol with a breakfast containing healthy fats, and with other fat-soluble supplements, such as: coq10, astaxanthin, and D3. I stopped taking NMNH and trans-resveratrol for a while, and really noticed the difference, so I’ll keep taking these now forever!