ecoNugenics formulas such as PADMA Basic work great for me, and is most noticeable with the problems I used to have with my knees.
I had ran out of it before & it was a while before I had replaced it, & my problems recurred, but once I replenished it back into my system, the problems went away, so I try to stay in the fix of it all by keep using what works. Being 75 & fairly active is tough on the body, so I appreciate quality supplements that perform.